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Mutagenesis Eszopiclone was clastogenic in in vitro (mouse lymphoma and chromosomal aberration) assays in mammalian cells. Eszopiclone was detrimental inside the in vitro bacterial gene mutation (Ames) assay and in an in vivo micronucleus assay.
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Paroxetine: Coadministration of solitary dose of eszopiclone and paroxetine generated no pharmacokinetic or pharmacodynamic conversation.